Prince Frederik of Luxembourg, son of Prince Robert and Princess Julie of Nassau, passed away on March 1 in Paris at the age of 22 after a lifelong struggle with POLG mitochondrial disease.
His family confirmed the news in an emotional statement on the POLG Foundation’s website. “It is with a very heavy heart that my wife and I would like to inform you of the passing of our son, The POLG Foundation founder and creative director, Frederik,” Prince Robert wrote.
Frederik was diagnosed with POLG mitochondrial disease at age 14 after years of unexplained health struggles. The rare genetic disorder affects the body’s ability to produce energy, leading to organ failure.
Despite his diagnosis, Frederik dedicated his life to advocating for research and awareness. In his final moments, Frederik called his loved ones to his bedside to say goodbye. “Frederik found the strength and the courage to say goodbye to each of us in turn,” Prince Robert said. “Even in his last moments, his humour and boundless compassion compelled him to leave us with one last laugh… to cheer us all up.”
Frederik’s health had declined in recent weeks after being hospitalised with pneumonia and another severe infection.
Even in his last days, Frederik continued to engage with the world. His father recalled that he still had his alarm set for an Italian lesson on Duolingo.
His family, struggling with his loss, are holding onto his words. “Go outside when the sun is shining,” he had written in a note on his phone.
What is POLG
POLG disease is a genetic disorder that prevents the body from producing enough energy, leading to organ failure. It is caused by mutations in the POLG and POLG2 genes, which affect mitochondria—the body’s power source. Symptoms vary but often include muscle weakness, seizures, and liver failure. There is no cure, and the disease worsens over time.
Once thought to be rare, the disease now affect about 1 in 5,000 people worldwide, making them the second most common serious genetic disorder after cystic fibrosis.
